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Sperm-inspired robots could be the next big thing in drug delivery

These flea-sized drones would swim through patients' blood vessels to deliver life-saving medication.

by Brandon Specktor, Live Science / Oct. 2, 2018 / 10:47 PM GMT+1

Human sperm, artwork

It turns out sperm like these are the perfect shape for speedy drug delivery.Sciepro / Science Photo Library/Getty Images

Scientists in the United Kingdom have turned to the humble human sperm in their quest to design the ultimate swimming robot.

Made of a tiny magnetic head and squiggly elastic tail, the flea-size drones look and swim much like their spermy counterparts, with a few big differences: These swimmers are guided by shifting electromagnetic currents, controlled externally by scientists. Oh, and also: They won't get you pregnant.

According to Feodor Ogrin, a lecturer at the University of Exeter in England and co-author of a new study published Sept. 4 describing the swimmers in the journal Physics of Fluids, robo-sperm like these could provide a cheap, efficient template for drug-delivery systems in human patients.

"The swimmers could one day be used to direct drugs to the right areas of the body by swimming through blood vessels," Ogrin said in a statement. "Developing this technology could radically change the way we do medicine."

The idea of designing sperm-inspired robot swimmers has been tested in several previous studies, but Ogrin and colleagues believe they've hit on an inexpensive design (the tails can be made with simple, 3D-printed molds) and the perfect head-to-tail ratio.

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In their new study, the team of Exeter scientists built several swimmer prototypes with tails ranging from 0.04 inch to 0.5 inch (1 to 12 millimeters) long. The team set these swimmers loose in fluids of varying viscosities, then coaxed them forward with electromagnetic currents of varying intensities. Just as a sperm cell whips and undulates its tail (or "flagellum") to propel itself forward, these magnetic swimmers followed the path of the current with tails whipping behind them.

Ultimately, the researchers found that swimmers with 0.15-inch-long (4 mm) tails moved quickest and with the best control.

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With the perfect sperm-tail-dynamics settled, the team tested a second hypothesis: If these sperm-like swimmers were fixed in place in a narrow channel (like an artery, for example), could they use their tail motion to pump fluids forward through that channel? To find out, the researchers attached a swimmer to a post at one end of a small, rectangular trough inside a petri dish, then filled it with fluid. Sure enough, when the team turned on an electromagnetic current to stimulate the swimmer, the little drone's tail movements were powerful enough to pump fluid continuously through the trough. (You can see this part of the experiment in action in a video taken in the lab.)

That's great news for tiny, sperm-inspired robot enthusiasts everywhere. The next step, the researchers wrote, will be going even smaller. While a 0.15-inch-long (4 mm) robot could swim comfortably through an adult's aorta (a blood vessel with a diameter of about 1 inch, or 25 mm), according to "The Oxford Companion to The Body," many human capillaries are only about 8 micrometers wide — about 3,000 times smaller than the aorta and 500 times smaller than the current swimming spermbots. With an average length of 50 micrometers, it seems the humble human sperm cell still has a lot to teach us.

Originally published on Live Science.

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Luke Posted on October 23, 2018 05:25

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